Research using stem cell-derived models of early human development suggests that PFOS, a persistent substance belonging to ...

Cytonemes are tendril-like appendages that developing cells use to communicate across large distances. Their cargo—including ...

WNT proteins have been recognized as key regulators of skeletal health. However, developing WNT-associated bone anabolic agents is clinically challenging and expensive. Here we identify the ...

The Hedgehog (Hh) signalling pathway is a highly conserved mechanism that directs cell fate, patterning and tissue homeostasis throughout embryogenesis and adult life. Signalling is initiated when a ...

A cell culture study reveals that intracellular calcium depletion does not impair Sonic Hedgehog signaling, whereas excessive extracellular calcium inhibits pathway activation.

In the brain, highly specific connections called synapses link nerve cells and transmit electrical signals in a targeted manner. Despite decades of research, how synapses form during brain development ...

Explore how oncogenes and signaling pathways converge and diverge in cancer, shaping diagnostic and therapeutic strategies for personalized interventions. This convergence is accompanied by ...