Scientists filmed a tiny protein complex changing shape and gripping DNA, revealing how it captures and holds different DNA ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

Targeting telomeric damage-induced non-coding RNAs with antisense oligonucleotides suppresses DNA damage signaling and ...

DNA can be damaged by normal cellular processes as well as external factors such as UV radiation and chemicals. Such damage can lead to breaks in the DNA strand. If DNA damage is not properly repaired ...

For decades, the central dogma of molecular biology—DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease. This model explained ...

Determining protein structures requires crystals, but getting proteins to crystallize has long depended on a slow, unpredictable process of trial and error ...

Replication Protein A (RPA) is the principal single-stranded DNA (ssDNA)-binding complex in eukaryotic cells, orchestrating fundamental processes of DNA replication, repair and recombination. As a ...

Scientists have captured the most detailed structural images to date of a specific type of protein's DNA repair process, a finding that could reveal ways to inhibit the effects of BRCA1 and BRCA2 ...