Ketoreductases (KRs) are the most widespread tailoring domains found in individual modules of assembly line polyketide synthases (PKSs), and are responsible for controlling the configurations of both ...

Attempts at generating novel chemistries by genetically manipulating polyketide synthases (PKSs) usually result in no detectable or poor product yield. Understanding processes that drive the evolution ...

Video shows the mechanism of action of a polyketide synthase module reported by a University of Michigan research team. A new study solves long-standing mysteries about how bacterial ...

Polyketides are a large class of secondary metabolites that have become indispensible in the modern medicine. They are made by massive enzymes called polyketide synthases, which contain multiple ...