A systematic wet-heating study demonstrates that four hours of Maillard glycation optimizes the structural flexibility, ...

Researchers have introduced HandShake, a sequence-only model that accurately predicts partner-specific protein binding sites ...

On Wednesday, the Nobel Committee announced that it had awarded the Nobel Prize in chemistry to researchers who pioneered major breakthroughs in computational chemistry. These include two researchers ...

The effect of evolution on the fundamental thermodynamic properties of proteins has been unclear. Ancestral protein reconstruction has now shown that Earth’s ancient high temperatures promoted entropy ...

Newswise — Biologists and computational scientists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory recently refined two artificial intelligence (AI) programs originally built ...

A new LMU study shows how proteins function reliably even without a stable 3D structure—and the crucial importance not only of short sequence motifs, but also of chemical characteristics. Many ...

In the ERC project HelixMold, a team from TU Graz developed a method for the computer-based design of artificial proteins, with a focus on custom biocatalysts for pharmaceutical applications or the ...

Within the past few years, models that can predict the structure or function of proteins have been widely used for a variety of biological applications, such as identifying drug targets and designing ...

In the wee hours of an October morning, David Baker, a protein biologist at the University of Washington (UW), received the most-awaited phone call in a scientist’s career. Halfway around the world, ...

This fully updated volume explores a wide array of new and state-of-the-art tools and resources for protein function prediction. Beginning with in-depth overviews of essential underlying computational ...

In genetics, one harmful variant can be enough to cause disease—but two can make it far more severe. One notable example is KJ, an infant diagnosed with a rare urea cycle disorder with a grim ...